Dominios cognitivos afectados en pacientes con depresión mayor

Neuroscience

March 3, 2025

El compromiso de la función cognitiva es un componente central del trastorno depresivo mayor (TDM) y está asociado a:1-9

• Deterioro funcional significativo.

• Reducción importante del éxito del tratamiento psicoterapéutico.

• Disminución sustancial de la calidad de vida.

• Incremento del suicidio.

Hasta 70%-90% de los pacientes con trastorno depresivo mayor presentan deficien cias cognitivas.1,5

De todos los inhibidores selectivos de la recaptacion de la serotonina (ISRS) Fluvoxamina es Potente agonista de receptor sigma 1 lo que permite la mejoría de la función cognitiva.3,9,11-14

Referencias

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  5. Liu J, Dong Q, Lu X, et al. Exploration of major cognitive deficits in medication-free patients with major depressive disorder. Front Psychiatry 2019; 10: 836-43.
  6. Kriesche D, Woll CFJ, Tschentscher N, et al. Neurocognitive deficits in depression: a systematic review of cognitive impairment in the acute and remitted state. Eur Arch Psychiatry Clin Neurosci 2023; 273: 1105-28.
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  13. Nishimura T, Ishima T, Iyo M, Hashimoto K. Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways. PLoS One 2008; 3: e2558.
  14. Härtter S, Wang X, Weigmann H, et al. Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin. J Clin Psychopharmacol 2001; 21: 167-74.
  15. Von Bahar C, Ursing C, Yasui N, et al. Fluvoxamine but not citalopram increases serum melatonin in healthy subjects – an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin. Eur J Clin Pharmacol 2000; 56: 123-7.
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